Cisplatin

A member of the family of chemotherapy drugs known as platinum containing compounds or alkylating agents, Cisplatin has been in use for many years and was the first member in its class of drugs. In addition to treating mesothelioma, it has historically been used to treat testicular, bladder, ovarian, lung, and stomach cancers as well.

Technically speaking, cisplatin acts by cross-linking DNA in various different ways, making it impossible for rapidly dividing cells to duplicate their DNA for mitosis.  When it was approved for use in 1978, it transformed the treatment of many different types of cancers.  It is often used together with other chemo drugs.

Cisplatin’s side effects can be more severe than its more recent counterparts, as is usually the case with drugs that have been on the market for several decades.  As new drugs are developed, scientists determine ways to lessen serious side effects.

Treatment

• Cisplatin is administered intravenously or through a central line inserted for the purpose of prolonged chemotherapy.

Side Effects

• Kidney failure (nephrotoxicity) – This is a major concern with cisplatin.  Patients will be advised to drink lots of water and doctors will determine the patient’s renal function before suggesting the use of this drug.
• Nerve damage
• Nausea and vomiting – Your doctor will try to control this symptom with other forms of medication as these side effects can be quite severe with cisplatin. 
• Hair loss
• Hearing loss
• Increased chance of infection due to reduction in white blood cells
• Inability to clot due to reduction in platelets
• Fatigue